The 16 x 16 Initiative recognizes, values and supports the positive role that young women and men play as leaders of 16 youth organizations, movements and networks and as agents of change and partners in building peaceful, just and inclusive societies. It is supported by the United Nations Development Programme (UNDP) and implemented through the UNDP Youth Global Programme for Sustainable Development and Peace. The paper presents highlights from the first phase of the 16 x 16 Initiative (2019-2021) and looks ahead by reflecting on how best to promote, support and facilitate meaningful youth engagement and multi-stakeholder collaboration for the implementation, monitoring and review of the SDGs.