Since the 1990s, more than 30 countries have established some form of anticorruption agency (ACA) or commission as a key tactic in their efforts to fight corruption. USAID Missions and other international donors are faced with many questions as they provide advice and assistance to host country governments on their efforts to combat corruption. This program brief is intended to assist DG Officers by outlining the critical questions around the establishment and workings of a host country’s ACA. The note also provides substantive input on how the answers to those questions may affect the effectiveness of donor support for an ACA.